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Description

This study presents a biologically guided strategy to enhance dental implant osseointegration by integrating peri-implant transcriptomic analysis with molecular docking simulations to identify bioactive surface molecules that may promote osteoblast attachment, extracellular matrix formation, and early bone healing. By aligning implant surface chemistry with host tissue biology, this translational in silico workflow offers a rapid, cost-effective pathway toward next-generation bioactive coatings designed to improve healing, strengthen bone–implant integration, and support long-term clinical success.

Disciplines

Dental Materials

Keywords

osseointegration; bioactive coatings; implant surface; transcriptomics; molecular docking; translational biomaterials

Document Type

Poster

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Bridging Biology and Biomaterials: In Silico Discovery of Bioactive Surface Molecules to Enhance Osseointegration

This study presents a biologically guided strategy to enhance dental implant osseointegration by integrating peri-implant transcriptomic analysis with molecular docking simulations to identify bioactive surface molecules that may promote osteoblast attachment, extracellular matrix formation, and early bone healing. By aligning implant surface chemistry with host tissue biology, this translational in silico workflow offers a rapid, cost-effective pathway toward next-generation bioactive coatings designed to improve healing, strengthen bone–implant integration, and support long-term clinical success.