Description
Persistent endodontic infections can endure despite technically adequate root canal treatment, reflecting a biological transition from microbial invasion to a host-driven chronic inflammatory state. This study applied a computational network biology approach to model host–microbe molecular interactions in chronic apical periodontitis and to identify key network hubs sustaining inflammation and periapical bone resorption.
Disciplines
Dentistry | Endodontics and Endodontology | Medicine and Health Sciences
Keywords
Chronic apical periodontitis; Host–pathogen interactions; Network biology; NF-κB signaling; Oxidative stress
Document Type
Poster
Recommended Citation
O’Callaghan, Janaki; Bhandi, Shilpa; Patil, Shankargounga; and Licari, Frank W., "Computational Network Biology of Host Microbe Crosstalk in Persistent Endodontic Inflammation" (2026). Annual Research Symposium. 1.
https://ecommons.roseman.edu/researchsymposium/2026/basic_sciences/1
Included in
Computational Network Biology of Host Microbe Crosstalk in Persistent Endodontic Inflammation
Persistent endodontic infections can endure despite technically adequate root canal treatment, reflecting a biological transition from microbial invasion to a host-driven chronic inflammatory state. This study applied a computational network biology approach to model host–microbe molecular interactions in chronic apical periodontitis and to identify key network hubs sustaining inflammation and periapical bone resorption.