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Publication Date

12-20-2024

Description

Introduction: Accelerated orthodontics aims to shorten treatment duration while improving patient comfort. Injectable platelet-rich fibrin (i-PRF) has been proposed to enhance orthodontic tooth movement (OTM) by stimulating bone remodeling. This study evaluates the effect of i-PRF on space closure rates, anchor loss, and salivary biomarkers (ALP, AST, and LDH) during orthodontic retraction.

Materials and Methods: Twenty-four participants requiring extractions and space closure were divided into two groups (n = 12 each). Group A (experimental) received i-PRF, while Group B (control) did not. Space closure, anchor loss, and salivary enzyme activity were measured at T0 (baseline), T1 (3 weeks), T2 (6 weeks), and T3 (9 weeks). Statistical analysis included the Mann-Whitney and independent t-tests.

Results: Eight participants remained in each group after follow-up losses. In the maxillary arch, Group A had a space closure rate of 1.4 ± 1.9 mm at T3 (T0: 10.8 ± 3.01 mm), while Group B reduced from 11.1 ± 2.0 mm at T0 to 4.9 ± 1.5 mm at T3. In the mandibular arch, Group A had a closure rate of 2.6 ± 2.0 mm at T3 (T0: 9.5 ± 2.5 mm), while Group B decreased from 10.0 ± 2.7 mm at T0 to 4.7 ± 2.3 mm at T3. Anchor loss was not significantly different between groups.

Conclusion: i-PRF accelerated space closure, with statistical significance in the maxilla at T2 and T3 and the mandible at T2, without affecting anchorage stability.

Clinical Significance: i-PRF may be a safe and effective adjunct in orthodontic treatment, reducing treatment duration without compromising anchorage.

Disciplines

Orthodontics and Orthodontology

Keywords

Anchor loss, injectable platelet-rich fibrin, regional accelerating phenomenon, space closure

Document Type

Poster

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Enhancing Orthodontic Retraction: A Randomized Controlled Trial on Injectable Platelet-Rich Fibrin's Impact on Tooth Movement

Introduction: Accelerated orthodontics aims to shorten treatment duration while improving patient comfort. Injectable platelet-rich fibrin (i-PRF) has been proposed to enhance orthodontic tooth movement (OTM) by stimulating bone remodeling. This study evaluates the effect of i-PRF on space closure rates, anchor loss, and salivary biomarkers (ALP, AST, and LDH) during orthodontic retraction.

Materials and Methods: Twenty-four participants requiring extractions and space closure were divided into two groups (n = 12 each). Group A (experimental) received i-PRF, while Group B (control) did not. Space closure, anchor loss, and salivary enzyme activity were measured at T0 (baseline), T1 (3 weeks), T2 (6 weeks), and T3 (9 weeks). Statistical analysis included the Mann-Whitney and independent t-tests.

Results: Eight participants remained in each group after follow-up losses. In the maxillary arch, Group A had a space closure rate of 1.4 ± 1.9 mm at T3 (T0: 10.8 ± 3.01 mm), while Group B reduced from 11.1 ± 2.0 mm at T0 to 4.9 ± 1.5 mm at T3. In the mandibular arch, Group A had a closure rate of 2.6 ± 2.0 mm at T3 (T0: 9.5 ± 2.5 mm), while Group B decreased from 10.0 ± 2.7 mm at T0 to 4.7 ± 2.3 mm at T3. Anchor loss was not significantly different between groups.

Conclusion: i-PRF accelerated space closure, with statistical significance in the maxilla at T2 and T3 and the mandible at T2, without affecting anchorage stability.

Clinical Significance: i-PRF may be a safe and effective adjunct in orthodontic treatment, reducing treatment duration without compromising anchorage.