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Description

Opioid-induced hyperalgesia (OIH) is an adverse effect of chronic opioid therapy, characterized by increased sensitivity to pain. This study will seek to determine if using resveratrol supplementation as an indirect enhancer to increase the expression of the KCC2 membrane transporter can alleviate the symptoms of OIH in human subjects.

Disciplines

Medical Neurobiology | Molecular and Cellular Neuroscience | Natural Products Chemistry and Pharmacognosy | Neurosciences | Substance Abuse and Addiction | Systems Neuroscience

Keywords

opioids, hyperalgesia, opioid-induced hyperalgesia, chronic pain, pain management

Document Type

Poster

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Investigating the Effects of Resveratrol on Opioid-Induced Hyperalgesia

Opioid-induced hyperalgesia (OIH) is an adverse effect of chronic opioid therapy, characterized by increased sensitivity to pain. This study will seek to determine if using resveratrol supplementation as an indirect enhancer to increase the expression of the KCC2 membrane transporter can alleviate the symptoms of OIH in human subjects.