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Description

In amelogenesis imperfecta, mutations are often found in the amelogenin gene. Inactivation of this amelogenin gene in 6-12 month old mice has led to root resorption in teeth and an increased number of osteoclasts in their bones. The objective of this study was to determine whether local injection of Emdogain (EMD) and low intensity pulsed ultrasound (LIPUS) application to the jaw has a synergistic effect on the regeneration of root resorption (RR) in Amelogenin knockout (AMEX) mice; the ideal model representing Amelogenesis Imperfecta.

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EFFECT OF LOW INTENSITY PULSED ULTRASOUND (LIPUS) AND EMDOGAIN ON ROOT RESORPTION IN AMELOGENIN KNOCKOUT (AMEX) MICE

In amelogenesis imperfecta, mutations are often found in the amelogenin gene. Inactivation of this amelogenin gene in 6-12 month old mice has led to root resorption in teeth and an increased number of osteoclasts in their bones. The objective of this study was to determine whether local injection of Emdogain (EMD) and low intensity pulsed ultrasound (LIPUS) application to the jaw has a synergistic effect on the regeneration of root resorption (RR) in Amelogenin knockout (AMEX) mice; the ideal model representing Amelogenesis Imperfecta.