Experimental Oximes as Organophosphate Preexposure Prophylaxis. Lessons from the Gulf War Syndrome
Publication Date
5-14-2024
Description
The present study was undertaken in order to determine if established or experimental K-oximes can protect from OP (paraoxon) toxicity. Rats that received only the OP were compared with those that had received oxime pretreatment before OP exposure. Best protection from paraoxon-induced mortality was observed after pretreatment with K-48. The other oximes were significantly less efficacious, but still significantly reduced the RR compared to the no-treatment group (paraoxon only). The FDA-approved agent for prophylaxis was least efficacious. The protective efficacy was unrelated to AChE inhibition.
Keywords
acetylcholinesterase, oximes, pyridostigmine, paraoxon
Document Type
Poster
Publication
Journal of Applied Toxicology
Conference Name
VA Research Symposium
Recommended Citation
Lorke, Dietrich; Nurulain, Syed M.; and Kuca, Kamil, "Experimental Oximes as Organophosphate Preexposure Prophylaxis. Lessons from the Gulf War Syndrome" (2024). COM Scholarship. 1.
https://ecommons.roseman.edu/comscholarship/1