CD5 co receptor plays a role in T cell metabolism
Description
During activation, Tcells undergo metabolic reprogramming, which helps determine their distinct functional fates. CD5isaco-receptor found on Tcells and plays a significant role in regulating Tcell thymic development, signaling, and cytokine production. Although CD5 is best known as a regulatory core captor during selection in Tcell development, it has been reported to play a regulatory role similar to PD-1 and CTLA 4. Upon Tcell activation. We have found that CD5 levels influence calcium mobilization and Tcell activation. Differential calcium mobilization, calcineurin function, and NFAT are known to affect glycolysis and mitochondrial respiration. Previous studies have shown that CD5 knock out mice (CD5KO) have increased Tcell activation, leading to elevated levels of cytokine production and Tcell proliferation. These functional changes suggest that CD5 may be affecting metabolic reprogramming. We hypothesized that CD5 deficient Tcells have different bioenergetic demands that affect metabolic pathways key to Tcell activation and function. We evaluated the effects of the CD5 co-receptor on metabolism by measuring the metabolic profiles of CD5KO and wild type Tcells. Our preliminary data suggests that CD5KOT cells have higher mitochondrial respiration than wild type Tcells. Thus, CD5 may play an important role in metabolic programing in Tcells and could potentially be useful used in modulating the Tcell response in the tumor microenvironment.
CD5 co receptor plays a role in T cell metabolism
During activation, Tcells undergo metabolic reprogramming, which helps determine their distinct functional fates. CD5isaco-receptor found on Tcells and plays a significant role in regulating Tcell thymic development, signaling, and cytokine production. Although CD5 is best known as a regulatory core captor during selection in Tcell development, it has been reported to play a regulatory role similar to PD-1 and CTLA 4. Upon Tcell activation. We have found that CD5 levels influence calcium mobilization and Tcell activation. Differential calcium mobilization, calcineurin function, and NFAT are known to affect glycolysis and mitochondrial respiration. Previous studies have shown that CD5 knock out mice (CD5KO) have increased Tcell activation, leading to elevated levels of cytokine production and Tcell proliferation. These functional changes suggest that CD5 may be affecting metabolic reprogramming. We hypothesized that CD5 deficient Tcells have different bioenergetic demands that affect metabolic pathways key to Tcell activation and function. We evaluated the effects of the CD5 co-receptor on metabolism by measuring the metabolic profiles of CD5KO and wild type Tcells. Our preliminary data suggests that CD5KOT cells have higher mitochondrial respiration than wild type Tcells. Thus, CD5 may play an important role in metabolic programing in Tcells and could potentially be useful used in modulating the Tcell response in the tumor microenvironment.
https://ecommons.roseman.edu/researchsymposium/2021/postergroup1/4