Linking Subgingival Bacterial Levels to Gingival Gene-Expression Patterns to Prioritize Host Response Pathways in Periodontitis

Josten R. Daneshmayeh, Roseman University of Health Sciences
Shilpa Bhandi, Roseman University of Health Sciences
Frank W. Licari, Roseman University of Health Sciences
Shankargouda Patil, Roseman University of Health Sciences

Description

Using paired plaque and gingival transcriptome records and an independent disease health validation cohort, we found that high burdens of key periodontal pathogens track with thousands of gingival expression changes and that diseased sites show broad enrichment of immune, apoptosis, and signaling pathways consistent with established periodontitis biology.

This paper has been withdrawn.
 

Linking Subgingival Bacterial Levels to Gingival Gene-Expression Patterns to Prioritize Host Response Pathways in Periodontitis

Using paired plaque and gingival transcriptome records and an independent disease health validation cohort, we found that high burdens of key periodontal pathogens track with thousands of gingival expression changes and that diseased sites show broad enrichment of immune, apoptosis, and signaling pathways consistent with established periodontitis biology.