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Description

Migraines affect roughly 1-in-6 males and 1-in-5 females in the United States. Of these, approximately 5-30% experience intractable migraines, or migraines resistant to abortive treatments. Despite this large population, relatively little is known about intractable migraines compared to other types of migraines. Our recent work indicates that reactive hypoglycemia is common among these individuals. Additionally, empirical evidence suggests that individuals in families with chronic intractable migraines are more likely to have the same condition than people of the general population, suggesting a possible genetic link between both migraines and metabolic abnormalities. Previous Genome Wide Association Studies (GWAS) have found several genetic markers for migraines, but the studies have not differentiated groups by important factors including severity and frequency of migraines or treatment response. Furthermore, GWA studies investigate only common variation. Despite these limitations, a variant in the LEPR gene (rs751167), the leptin receptor gene was found to be significantly associated with migraines. Variants in the LEPR gene are associated with weight gain and metabolic syndrome, indicating a link between metabolism and migraines. In the present study, we aim to broaden the scope, investigating chronic intractable migraine with reactive hypoglycemia specifically, and using all variant types including small insertions/deletions, rare variants, and copy number variants. To investigate heritability, we will take pedigrees of individuals that fit this phenotype.

Disciplines

Medical Education | Medical Sciences | Medicine and Health Sciences | Primary Care | Scholarship of Teaching and Learning

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Investigating the Genetics of Chronic Intractable Migraine with Reactive Hypoglycemia

Migraines affect roughly 1-in-6 males and 1-in-5 females in the United States. Of these, approximately 5-30% experience intractable migraines, or migraines resistant to abortive treatments. Despite this large population, relatively little is known about intractable migraines compared to other types of migraines. Our recent work indicates that reactive hypoglycemia is common among these individuals. Additionally, empirical evidence suggests that individuals in families with chronic intractable migraines are more likely to have the same condition than people of the general population, suggesting a possible genetic link between both migraines and metabolic abnormalities. Previous Genome Wide Association Studies (GWAS) have found several genetic markers for migraines, but the studies have not differentiated groups by important factors including severity and frequency of migraines or treatment response. Furthermore, GWA studies investigate only common variation. Despite these limitations, a variant in the LEPR gene (rs751167), the leptin receptor gene was found to be significantly associated with migraines. Variants in the LEPR gene are associated with weight gain and metabolic syndrome, indicating a link between metabolism and migraines. In the present study, we aim to broaden the scope, investigating chronic intractable migraine with reactive hypoglycemia specifically, and using all variant types including small insertions/deletions, rare variants, and copy number variants. To investigate heritability, we will take pedigrees of individuals that fit this phenotype.