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Uma SFollow

Description

Autologous Platelet rich fibrin (PRF) has gained clinical significance in recent years for regeneration procedures. Advanced approaches, including the combination of PRF with drugs (simvastatin) that up regulate intrinsic bone growth factors that improve periodontal regeneration are of great interest. The aim of the study was to compare the drug release kinetics & cell viability analysis of simvastatin loaded A-PRF versus T-PRF and which one can be used as a potential carrier for simvastatin in terms of sustained release.

Disciplines

Periodontics and Periodontology

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Unveiling the dynamics: Comparing drug release and cell viability of Advanced-Plate Rich Fibrin(A-PRF) and Titanium prepared Platelet rich Fibrin(T-PRF) both loaded with simvastatin - An in-vitro study

Autologous Platelet rich fibrin (PRF) has gained clinical significance in recent years for regeneration procedures. Advanced approaches, including the combination of PRF with drugs (simvastatin) that up regulate intrinsic bone growth factors that improve periodontal regeneration are of great interest. The aim of the study was to compare the drug release kinetics & cell viability analysis of simvastatin loaded A-PRF versus T-PRF and which one can be used as a potential carrier for simvastatin in terms of sustained release.